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Article

Establishment of a Common Marmoset Lineage Carrying a Frameshift Mutation in SETD1A, a Schizophrenia Risk Gene.

Journal of neurochemistry - 1 Sept 2026

Wei Zefeng, Nakao Harumi, Hiraoka Yuichi, Harbers Maria, Abe Yukiko, Goto Motoki, Tamano Moe, Saeki Mai, Kishi Yusuke, Aiba Atsu

Abstract excerpt

Appropriate histone modifications are essential for maintaining functional chromatin structure and gene expression, and dysfunction of their regulators has been linked to a variety of diseases. Among these modifications, trimethylation of lysine 4 on histone H3 (H3K4me3) is a well-characterized epigenetic mark enriched at transcription start sites of actively transcribed genes. H3K4me3 regulates gene...

Read the complete abstract on PubMed

Topics

Animals
Histone-Lysine N-Methyltransferase
Frameshift Mutation
Callithrix
Schizophrenia
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals, Genetically Modified

Histones

Male

Epigenesis, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42689854
DOI: 10.1111/jnc.70546
PMCID: PMC13539942

Genes

SETD1A
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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