A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges.

doi:10.1186/s43556-026-00560-y

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A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges.

Molecular biomedicine - 3 Sept 2026

Xu Jiali, Peng Rui, Yuan Longhai, Zhang Huan, Tang Cong, Zhou Yanan, Yang Hao, Yang Yun, Huang Qing, Wang Junbin, Chen Hongyu, Quan Wenqi, Li Baisheng, Sun Qiangming, Lu Shuaiyao

Abstract excerpt

The continued antigenic evolution of SARS-CoV-2 Omicron subvariants has progressively eroded vaccine-elicited protective immunity, driving demand for next-generation candidates that confer broad-spectrum protection against phylogenetically divergent strains. Here we report the design and preclinical evaluation of SV, an mRNA vaccine encoding a heterodimeric receptor-binding domain (RBD) antigen. In this...

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Topics

Animals
Mice
Mice, Inbred BALB C
SARS-CoV-2
COVID-19 Vaccines
COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

mRNA Vaccines

Spike Glycoprotein, Coronavirus

Antibodies, Viral

Antibodies, Neutralizing

Mutation

Humans

Source

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Identifiers

PMID: 42687061
DOI: 10.1186/s43556-026-00560-y
PMCID: PMC13538340

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