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Article

Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice

4 Jan 2022

Abstract excerpt

The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antibody responses...

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PMID: 34983583
DOI: 10.1186/s12985-021-01737-3

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