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Article

Parallel routes of human carcinoma development: implications of the age-specific incidence data.

PloS one - 23 Sept 2009

Brody James P

Abstract excerpt

BACKGROUND: The multi-stage hypothesis suggests that cancers develop through a single defined series of genetic alterations. This hypothesis was first suggested over 50 years ago based upon age-specific incidence data. However, recent molecular studies of tumors indicate that multiple routes exist to the formation of cancer, not a single route. This parallel route hypothesis has not been tested with age-specific...

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Identifiers

PMID: 19774079
DOI: 10.1371/journal.pone.0007053
PMCID: PMC2743810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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