Association of MDM2 rs2279744 and rs937282 polymorphisms with breast cancer susceptibility and circulating MDM2 and p53 levels in Bangladeshi women: A case-control study.

doi:10.1371/journal.pone.0350622

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Article

Association of MDM2 rs2279744 and rs937282 polymorphisms with breast cancer susceptibility and circulating MDM2 and p53 levels in Bangladeshi women: A case-control study.

PloS one - 1 Jan 2026

Chowdhury Mahim Hassan, Islam Farzana, Khan Adiba Ayesha, Siddique Md Ayman, Hasan Nushaiba Binte, Samrat Mahinul Islam, Tanisha Mehrin Haque, Tasnim Jarin, Mahjabin Samiha, Islam Md Nazmul, Haque Md Aminul

Abstract excerpt

BACKGROUND: The MDM2-p53 signaling pathway plays a central role in tumor suppression, and genetic variants that disrupt this pathway may influence breast cancer (BC) susceptibility. However, data from South Asian populations, particularly Bangladesh, remain limited. METHODS: A case-control study was conducted in Bangladeshi women, including BC patients and healthy controls (HCs). Genotyping of MDM2 polymorphisms...

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Topics

Humans
Female
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53
Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Case-Control Studies

Genetic Predisposition to Disease

Bangladesh

Middle Aged

Polymorphism, Single Nucleotide

Adult

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42678985
DOI: 10.1371/journal.pone.0350622
PMCID: PMC13533348

Genes

MDM2
TG

Provenance

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