Serum IL-38 and the rs7599662 polymorphism: novel biomarkers for pediatric idiopathic nephrotic syndrome.

doi:10.1186/s13052-026-02327-1

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Article

Serum IL-38 and the rs7599662 polymorphism: novel biomarkers for pediatric idiopathic nephrotic syndrome.

Italian journal of pediatrics - 27 Aug 2026

Hussein Sherin Khamis, Morsi Maha Hosni, Abdelaleem Omayma O, Sayed Ahmed Doaa Ezzat, Ahmed Hassanein Doha Elsayed, Ali Marwa A, Abdelbadie Shaimaa, Gamal El Din Wahba Ahmed Mohamed, Elsary Asmaa Younis, Safar Heba, Fares Reham

Abstract excerpt

BACKGROUND: Idiopathic nephrotic syndrome (INS) is the most common chronic glomerular disorder in children and is characterized by a variable response to corticosteroid therapy. Interleukin-38 (IL-38), an anti-inflammatory cytokine, and its gene polymorphisms may influence disease susceptibility and treatment outcomes. This study investigated the associations between serum IL-38 levels, the rs7599662 gene...

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PMID: 42665855
DOI: 10.1186/s13052-026-02327-1
PMCID: PMC13523273

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