Article
FCGR2A single nucleotide polymorphism confers susceptibility to childhood-onset idiopathic nephrotic syndrome.
Immunology letters - 1 Jan 2018
Rossi Giovanni M, Bonatti Francesco, Adorni Alessia, Alberici Federico, Bodria Monica, Bonanni Alice, Ghiggeri Gian M, Martorana Davide, Vaglio Augusto
Abstract excerpt
Childhood-onset idiopathic nephrotic syndrome affects 1.15-3.4 children/100,000 children/year in Western Countries. Immune-mediated mechanisms, particularly T cell-mediated, are thought to play a key pathogenic role. The genetic basis of the disease is still poorly understood. We tested the association between single nucleotide polymorphisms (SNPs) of four genes encoding Fc gamma receptors (FCGR2A, FCGR2B,...
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