Article
Dynamic phenotyping of radioiodine-refractory differentiated thyroid cancer: thyroglobulin trajectories, dual-modal imaging, and genotype-defined treatment resistance.
Frontiers in endocrinology - 1 Jan 2026
Tan Gongxun, Zhang Yue, Mao Zhenwei, Zhang Chuan, Fu Jingjing, Wang Feng, Zhu Canhong, Zhou Jin, Jin Bingquan, Xu Ying, Qin Rong, Shao Xun, Zhang Lele, Li Shaohua, Gu Qian
Abstract excerpt
Background: Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is a clinically aggressive disease state with limited treatment options. While individual biomarkers, imaging modalities, and genomic drivers have each been studied in isolation, the dynamic relationships among longitudinal thyroglobulin kinetics, evolving dual-modal imaging phenotypes, and underlying genotypes, together with their...
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