The Effect of Germline Pathogenic Variants in the Upgrade Rate to Breast Cancer Among Patients Diagnosed With Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ on Core Needle Biopsy.

doi:10.1016/j.clbc.2026.07.030

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The Effect of Germline Pathogenic Variants in the Upgrade Rate to Breast Cancer Among Patients Diagnosed With Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ on Core Needle Biopsy.

Clinical breast cancer - 1 Sept 2026

Ijaz Komal, Alston Broden, Bevers Therese, Arun Banu, Weber Diane, Yi Min, Hunt Kelly, Whitman Gary, Middleton Lavinia P

Abstract excerpt

INTRODUCTION: Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) are high-risk lesions that may be identified on biopsy performed for evaluation of radiologic abnormalities. Most women diagnosed with ALH and LCIS do not develop breast cancer. Treatment recommendations are ill-defined when these lesions are discovered in patients with germline pathogenic variants (PV) in breast cancer...

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Topics

Humans
Female
Breast Neoplasms
Biopsy, Large-Core Needle
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Breast Carcinoma In Situ

Hyperplasia

Carcinoma, Lobular

Genetic Predisposition to Disease

Aged

Adult

Genetic Testing

Breast

Mammography

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 42659732
DOI: 10.1016/j.clbc.2026.07.030

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