Multigene Germline Testing in Patients with DCIS vs Invasive Breast Cancer in a Large, Integrated Health Care System.

doi:10.1245/s10434-025-19053-3

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Multigene Germline Testing in Patients with DCIS vs Invasive Breast Cancer in a Large, Integrated Health Care System.

Annals of surgical oncology - 1 May 2026

Dzubnar Jessica M, Habel Laurel A, Jiang Sheng-Fang, Karlea Audrey, Hoodfar Elizabeth, Shim Veronica C

Abstract excerpt

BACKGROUND: Identification of germline pathogenic (PV) and likely pathogenic variants (LPV) can inform patients of their risk for breast cancer, empowering them to utilize risk-reducing strategies. National guidelines for germline testing are the same for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS); however, data on how testing and results compare for patients with DCIS versus IBC are...

Topics

Humans
Female
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Retrospective Studies
Germ-Line Mutation
Genetic Testing
Carcinoma, Ductal, Breast
Middle Aged
Delivery of Health Care, Integrated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Biomarkers, Tumor

Prognosis

Follow-Up Studies

Aged

Neoplasm Invasiveness

Genetic Predisposition to Disease

Adult

Source

Open in PubMed

Identifiers

PMID: 41530599
DOI: 10.1245/s10434-025-19053-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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