Article

Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination

2023-10-09

Abstract excerpt

<title>Abstract</title> <p>Coordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4+T cell signature’s predictive potential for post-vaccinal serological and CD8+T cell responses. A cytokine signature composed of four cytokines (IL-2, TNF-α, IP10, IL-9) excluding IFN-g and generated through machine learning, effectively predict...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3eb69cf4-b532-5fd5-ac8d-e96ded3d4759
DOI: 10.21203/rs.3.rs-3359568/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccinationDOI 10.21203/rs.3.rs-3359568/v1Read

Evaluation of the Immunomodulatory Effects of Interleukin-10 on Peripheral Blood Immune Cells of COVID-19 Patients: Implication for COVID-19 TherapySemantic proximity Read

Favourable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapiesSemantic proximity Read

Systemic IL-15, IFN-γ and IP-10/CXCL10 Signature Associated With Effective Immune Response in BNT162b2 mRNA Vaccine RecipientsSemantic proximity Read

Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturerSemantic proximity Read

Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infectionSemantic proximity Read

mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infectionSemantic proximity Read

Quantitative Insight into Immunopathology of SARS-CoV-2 Infection.Semantic proximity Read

T Cell-mediated Immune Response and Correlates of Inflammation and their relationship with COVID-19 clinical severity: not an intuitive guess.Semantic proximity Read

mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infectionSemantic proximity Read

Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus InfectionSemantic proximity Read

Anti-SARS-CoV-2 cellular immunity in 571 vaccinees assessed using an interferon-γ release assaySemantic proximity Read

Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humansSemantic proximity Read