Poor sleep quality is associated with symptom severity in schizophrenia, independent of chronotype and BDNF Val66Met genetic variant.

doi:10.1016/j.pnpbp.2026.111907

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Article

Poor sleep quality is associated with symptom severity in schizophrenia, independent of chronotype and BDNF Val66Met genetic variant.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2026

Kumar Anusree Ashok, Shaju Aisha, Sidharthan Midhun, John Jasmine, Mundedath Ranjitha, Haridas Nishanth J, Kakkolil Anish Palliyalil, Anitha Ayyappan, Ravindren Rajith K, Balan Shabeesh

Abstract excerpt

Sleep disturbances are prevalent in schizophrenia and are associated with symptom severity, yet findings remain inconsistent, reflecting unmeasured biological moderators. Chronotype and the BDNF genetic variant influence sleep regulation and schizophrenia-related phenotypes. However, their combined contribution to the sleep quality-symptom severity association remains unexplored. We aimed to characterise sleep...

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Topics

Humans
Brain-Derived Neurotrophic Factor
Chronotype
Male
Schizophrenia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Adult

Severity of Illness Index

Cross-Sectional Studies

Sleep Wake Disorders

Middle Aged

Sleep Quality

Genotype

Psychiatric Status Rating Scales

Polymorphism, Single Nucleotide

Valine

Source

Open in PubMed

Identifiers

PMID: 42648426
DOI: 10.1016/j.pnpbp.2026.111907

Genes

BDNF

Variants

Provenance

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