Identification and Thermal Stability Modification of a Zearalenone Lactone Hydrolase ZHD30L.

doi:10.3390/toxins18080324

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Identification and Thermal Stability Modification of a Zearalenone Lactone Hydrolase ZHD30L.

Toxins - 26 Jul 2026

Liu Xingsai, Zhao Fengguang, Sahibzada Kashif Iqbal, Zhang Yaping, Wei Shan, Tian Pingping, Wang Yingying, Hu Yuansen, Lv Yangyong

Abstract excerpt

In this study, a previously uncharacterized zearalenone lactone hydrolase, ZHD30L, from Knufia peltigerae was identified and characterized, and semi-rational design was employed to enhance its thermostability. The results indicate that the optimal reaction conditions for this enzyme are 40 °C and pH 9.0, under which it catalyzes the ring-opening of the ZEN lactone to generate the non-toxic product HZEN. The...

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Enzyme Stability
Hot Temperature
Hydrolases
Kinetics
Mutation
Temperature
Thermodynamics

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PMID: 42646752
DOI: 10.3390/toxins18080324
PMCID: PMC13517648

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