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Article

The Trp183 is essential in lactonohydrolase ZHD detoxifying zearalenone and zearalenols.

Biochemical and biophysical research communications - 19 Feb 2020

Zhou Hujian, Li Long, Zhan Bowen, Wang Sen, Li Jixi, Hu Xiao-Jian

Abstract excerpt

Lactonohydrolase ZHD can detoxify oestrogenic mycotoxin zearalenone and zearalenols through hydrolysis and decarboxylation. The detail mechanism, especially the role of Trp183, which interacts with substrate through p-π interaction and one hydrogen bond, is still unknown. The Trp183 mutants abolished activity to ZEN, α-ZOL and β-ZOL, except that W183F mutant retained about 40% activity against α-ZOL. In two...

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PMID: 31810602
DOI: 10.1016/j.bbrc.2019.11.178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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