Article
Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1.
PLoS pathogens - 1 Sept 2012
Seed Kimberley D, Faruque Shah M, Mekalanos John J, Calderwood Stephen B, Qadri Firdausi, Camilli Andrew
Abstract excerpt
The Vibrio cholerae lipopolysaccharide O1 antigen is a major target of bacteriophages and the human immune system and is of critical importance for vaccine design. We used an O1-specific lytic bacteriophage as a tool to probe the capacity of V. cholerae to alter its O1 antigen and identified a novel mechanism by which this organism can modulate O antigen expression and exhibit intra-strain heterogeneity. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.