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Article

Identifying SHROOM4 as a novel X-linked susceptibility gene for cerebral palsy in Chinese males.

BMC pediatrics - 21 Aug 2026

Su Yu, Xu Yiran, Cheng Ye, Qi Zheng, Li Jingzhou, Zhang Jin, Li Yunqian, Wang Ting, Zhang Junjie, Wang Xiaoyang, Zhu Changlian, Xing Qinghe

Abstract excerpt

BACKGROUND: Cerebral palsy (CP) is a leading cause of childhood motor disability with a notable male predominance, suggesting that X-linked genetic factors may contribute to CP susceptibility. Although SHROOM4 has been implicated in several neurodevelopmental disorders, its role in CP remains unclear. This study aimed to investigate the contribution of SHROOM4 variants to male CP susceptibility. METHODS:...

Topics

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Cerebral Palsy
China
Cytoskeletal Proteins
East Asian People
Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, X-Linked

Genetic Diseases, X-Linked

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Open in PubMed Open full text

Identifiers

PMID: 42632887
DOI: 10.1186/s12887-026-07486-y
PMCID: PMC13499302

Genes

CP
SHROOM4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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