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Article

X-chromosomal genetic variants and haplotype analysis in male cerebral palsy patients: insights into genetic susceptibility and sex-specific risk.

Journal of neurodevelopmental disorders - 3 Jul 2026

Su Yu, Wang Yangong, Cheng Ye, Xu Yiran, Qiao Yimeng, Xia Lei, Song Juan, Li Yunqian, Zhang Junjie, Sun Hongyuan, Wang Xiaoyang, Zhu Changlian, Xing Qinghe

Abstract excerpt

BACKGROUND: Cerebral palsy (CP) is a neurodevelopmental disorder with a significant male predisposition, yet the underlying genetic mechanisms driving this sex-specific risk remain poorly understood. Given the hemizygous state of X-linked variants in males, we hypothesized that X-chromosomal genetic variations may contribute to CP susceptibility in male patients. METHODS: We performed an X-chromosome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, X

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 42399817
DOI: 10.1186/s11689-026-09717-w
PMCID: PMC13332595

Genes

CP
UTP14A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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