Article
Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli.
The Journal of biological chemistry - 17 Oct 2008
Terrak Mohammed, Sauvage Eric, Derouaux Adeline, Dehareng Dominique, Bouhss Ahmed, Breukink Eefjan, Jeanjean Sylvie, Nguyen-Distèche Martine
Abstract excerpt
The peptidoglycan glycosyltransferase (GT) module of class A penicillin-binding proteins (PBPs) and monofunctional GTs catalyze glycan chain elongation of the bacterial cell wall. These enzymes belong to the GT51 family, are characterized by five conserved motifs, and have some fold similarity with the phage lambda lysozyme. In this work, we have systematically modified all the conserved amino acid residues of...
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