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Article

Genotype 2 Strains of Porcine Reproductive and Respiratory Syndrome Virus Dysregulate Alveolar Macrophage Cytokine Production via the Unfolded Protein Response.

Journal of virology - 15 Jan 2018

Chen Wei-Yu, Schniztlein William M, Calzada-Nova Gabriela, Zuckermann Federico A

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) infects alveolar macrophages (AMϕ), causing dysregulated alpha interferon (IFN-α) and tumor necrosis factor alpha (TNF-α) production through a mechanism(s) yet to be resolved. Here, we show that AMϕ infected with PRRSV secreted a reduced quantity of IFN-α following exposure of the cell to synthetic double-stranded RNA (dsRNA). This reduction did not...

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Identifiers

PMID: 29070690
DOI: 10.1128/JVI.01251-17
PMCID: PMC5752938

Genes

TNF
IFNA1

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