Article
Y Chromosome Haplogroups and Susceptibility to Esophageal Squamous Cell Carcinoma: An Exploratory Association and Diagnostic Modeling Study.
Molecular genetics & genomic medicine - 1 Aug 2026
Shi Xueji, Wang Nian, Zhou Wenjing, Zhong Huiyu, Liu Tangyuheng, Song Mengyuan, Zhou Yi, Song Xingbo
Abstract excerpt
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) showed remarkable male predominance, but the potential relevance of Y chromosome background remains unclear. This exploratory study investigated Y chromosome haplogroup distribution and its possible contribution to ESCC diagnostic modeling. METHODS: We recruited 517 male ESCC patients and 447 age-matched healthy men from Sichuan, China. Y chromosomal short...
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