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The genomic mutational landscape and its correlation with TMB, PD-L1 expression and CD8+ T cell infiltration in Chinese lung large cell neuroendocrine carcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2022

Li Ye, Shi Xinying, Mao Beibei, Wang Lingxiong, Wu Lijia, Li Jie, Jiao Shunchang

Abstract excerpt

OBJECTIVES: The aim of this study was to illustrate the genomic mutational landscape, tumor mutation burden (TMB), PD-L1 expression, CD8+ T cell infiltration and their prognostic value in resectable Lung large cell neuroendocrine carcinoma (LCNEC). MATERIALS AND METHODS: The tumor tissues and corresponding normal tissues of 37 LCNEC patients undergoing surgical resection were collected and determined by whole...

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PMID: 35287068
DOI: 10.1016/j.lungcan.2022.01.007

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