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Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas.

NMR in biomedicine - 1 Sept 2026

Cadin Capucine, Casagranda Stefano, Lejeune François Xavier, Golse Marianne, Mathon Bertrand, Dipasquale Ottavia, Papageorgakis Christos, Zucchelli Mauro, Mandonnet Emmanuel, Lehéricy Stéphane, Bielle Franck, Sanson Marc, Liebig Patrick, Zaiss Moritz, Nichelli Lucia, Branzoli Francesca

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect-weighted (NOEw) markers showed promise for glioma characterization, by probing protein-related tissue properties. However, their interpretation is confounded by direct water saturation, macromolecules (semi-solid magnetization...

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PMID: 42565483
DOI: 10.1002/nbm.70372
PMCID: PMC13449637

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