Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.

Journal of neuro-oncology - 19 May 2026

Zeyen Thomas, Decker Andreas, Krause Inga, Kroh Florian, Scheuble Julia, Friker Lea L, Pietsch Torsten, Regnery Sebastian, Effland Alexander, Weller Johannes, Schäfer Niklas, Radbruch Alexander, Herrlinger Ulrich, Paech Daniel

Abstract excerpt

PURPOSE: Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (APTw) chemical exchange saturation transfer (CEST) MRI reflects endogenous protein and peptide content, but its clinical and molecular correlates in therapy-naive glioblastoma, IDH-wildtype, remain incompletely understood. METHODS: This retrospective single-center...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Glioblastoma

Share to Isocitrate Dehydrogenase

Share to Magnetic Resonance Imaging

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42154346
DOI: 10.1007/s11060-026-05616-1
PMCID: PMC13186792

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.PMID 42154346Read ↗

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas.Semantic proximity Read ↗

CEST MRI Provides Amides/amines Surrogate Biomarkers for Treatment-naïve Glioma Sub-typingSemantic proximity Read ↗

Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T.Semantic proximity Read ↗

CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing.Semantic proximity Read ↗

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1Semantic proximity Read ↗

Diagnostic performance between MR amide proton transfer (APT) and diffusion kurtosis imaging (DKI) in glioma grading and IDH mutation status prediction at 3 T.Semantic proximity Read ↗

Fluid Suppression Techniques Combined With Amide Proton Transfer-Weighted Imaging for the Evaluation of Adult-Type Diffuse Gliomas.Semantic proximity Read ↗

Multicenter validation of amide proton transfer imaging for the classification of adult-type diffuse gliomas.Semantic proximity Read ↗

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.Semantic proximity Read ↗

Prediction of H3K27M-mutant Brainstem Glioma by Amide Proton Transfer Weighted Imaging and Its Derived RadiomicsSemantic proximity Read ↗

Multi-pool chemical exchange saturation transfer MRI in glioma grading, molecular subtyping and evaluating tumor proliferation.Semantic proximity Read ↗

Histological grade 2 and non-contrast-enhancing phenotype provide prognostic information complementary to DNA methylation classification in TERTp-mutant molecular glioblastomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.