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Article

Oxidative gaseous air pollutant exposure interacts with PNPLA3-I148M genotype to influence liver fat fraction and multi-omics profiles in young adults.

Environmental pollution (Barking, Essex : 1987) - 1 Mar 2025

Patterson William B, Young Nathan D, Holzhausen Elizabeth A, Lurmann Frederick, Liang Donghai, Walker Douglas I, Jones Dean P, Liao Jiawen, Chen Zhanghua, Conti David V, Chatzi Lida, Goodrich Jesse A, Alderete Tanya L

Abstract excerpt

PNPLA3-I148M genotype is the strongest predictive single-nucleotide polymorphism for liver fat. We examine whether PNPLA3-I148M modifies associations between oxidative gaseous air pollutant exposure (Oxwt) with i) liver fat and ii) multi-omics profiles of miRNAs and metabolites linked to liver fat. Participants were 69 young adults (17-22 years) from the Meta-AIR cohort. Prior-month residential Oxwt exposure...

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Identifiers

PMID: 39864653
DOI: 10.1016/j.envpol.2025.125692
PMCID: PMC11859754

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PNPLA3

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