Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype.

doi:10.1016/j.envres.2025.123320

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Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype.

Environmental research - 1 Jan 2026

Li Shiwen, Chen Jiawen Carmen, Costello Elizabeth, Walker Douglas I, Goodrich Jesse A, Dara Lily, Golden-Mason Lucy, Maretti-Mira Ana C, Bartell Scott M, Vieira Veronica M, Alderete Tanya L, Goran Michael I, Chen Zhanghua, Gilliland Frank D, Baumert Brittney O, Rock Sarah, Ducatman Alan, Eckel Sandrah P, Conti David V, McConnell Rob, Aung Max, Chatzi Lida

Abstract excerpt

Studies in youth on per- and polyfluoroalkyl substances (PFAS) exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. The study aimed to evaluate associations between PFAS and MASLD risk and the modifying role of age, lifestyle factors, and genetic risk. We analyzed data from two independent cohorts: the Study of Latino Adolescents at Risk of Type 2 Diabetes (SOLAR) following...

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Identifiers

PMID: 41232903
DOI: 10.1016/j.envres.2025.123320
PMCID: PMC12657100

Genes

PFAS
PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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