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Article

Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank.

Cell reports. Medicine - 20 Dec 2022

Park Joseph, MacLean Matthew T, Lucas Anastasia M, Torigian Drew A, Schneider Carolin V, Cherlin Tess, Xiao Brenda, Miller Jason E, Bradford Yuki, Judy Renae L, Verma Anurag, Damrauer Scott M, Ritchie Marylyn D, Witschey Walter R, Rader Daniel J

Abstract excerpt

Nonalcoholic fatty liver disease is common and highly heritable. Genetic studies of hepatic fat have not sufficiently addressed non-European and rare variants. In a medical biobank, we quantitate hepatic fat from clinical computed tomography (CT) scans via deep learning in 10,283 participants with whole-exome sequences available. We conduct exome-wide associations of single variants and rare predicted...

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Identifiers

PMID: 36513072
DOI: 10.1016/j.xcrm.2022.100855
PMCID: PMC9798024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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