Transient sub-MIC ciprofloxacin exposure produces a stress-conditioned Pseudomonas aeruginosa phenotype that enhances NF-κB activation and inflammatory injury in lung epithelial cells.

Abstract excerpt

Pseudomonas aeruginosa is a major opportunistic pathogen in healthcare-associated infections, and its management is increasingly complicated by antimicrobial resistance. In clinical settings, bacteria may be exposed to sub-minimum inhibitory concentration (sub-MIC) antibiotic gradients because of pharmacokinetic variation and uneven drug distribution. Although sub-MIC exposure can alter bacterial phenotypes and...

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• A549 Cells
• Ciprofloxacin
• Epithelial Cells
• Interleukin-8
• Lung