Article
Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG).
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Oct 2021
Mao Rong, Krautscheid Patti, Graham Rondell P, Ganguly Arupa, Shankar Suma, Ferber Matthew, Hegde Madhuri
Abstract excerpt
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and 30% of all cases of CRC are believed to have a familial component and up to one-third of these (10%) are hereditary. Pathogenic germline variants in multiple genes have been associated with predisposition to hereditary CRC or polyposis. Lynch syndrome (LS) is the most common hereditary CRC syndrome, caused by variants in the mismatch...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.