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The signature based on seven genomic instability-related genes could predict the prognosis of acute myeloid leukemia patients.

Hematology (Amsterdam, Netherlands) - 1 Dec 2022

Nie Lirong, Zhang Yuming, You Yuchan, Lin Changmei, Li Qinghua, Deng Wenbo, Ma Jingzhi, Luo Wenying, He Honghua

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is the most common acute blood malignancy in adults. The complicated and dynamic genomic instability (GI) is the most prominent feature of AML. Our study aimed to explore the prognostic value of GI-related genes in AML patients. METHODS: The mRNA data and mutation data were downloaded from the TCGA and GEO databases. Differential expression analyses were completed in limma...

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PMID: 35924822
DOI: 10.1080/16078454.2022.2107970

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