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Article

Causal link between circulating beta-hydroxybutyrate and myocardial infarction: Evidence from Mendelian randomization.

Medicine - 31 Jul 2026

Fan Wenwen, Wu Jidi, Mou Yulin, Wu Qianshi, Li Yanqun, Luo Li, Xu Yong, Huang Wei

Abstract excerpt

This study investigates the potential causal relationship between circulating ketone bodies, specifically beta-hydroxybutyrate (β-OHB), and the risk of myocardial infarction (MI), addressing limitations of confounding and reverse causation inherent in previous observational studies. We employed both univariable Mendelian randomization and multivariable Mendelian randomization (MVMR) analyses using publicly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42536565
DOI: 10.1097/MD.0000000000049920
PMCID: PMC13433103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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