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Article

Discordant neoplasms in monozygotic twins with a germline RECQL5 variant.

Cancer genetics - 1 Sept 2026

Husami Ammar, Mochizuki Aaron, Guan Qiaoning, Zhang Wenying, Nagaraj Chinmayee Bhimarao, Fabelo Corrie, Phillips Christine, Dawson Brian, Kim Sun Young

Abstract excerpt

RECQL5 is a member of the RecQ helicase family involved in DNA replication, homologous recombination, and maintenance of genomic stability. While germline pathogenic variants in other RecQ helicases cause established cancer predisposition syndromes, the role of RECQL5 in human cancer susceptibility remains uncertain. We report monozygotic adolescent twins with distinct tumors: dysembryoplastic neuroepithelial...

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Source

Identifiers

PMID: 42526351
DOI: 10.1016/j.cancergen.2026.07.006

Genes

RECQL5
SRI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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