KCNK4 c.730G>C/p.Ala244Pro Promotes Gingival Fibroblast Proliferation and Fibrosis Through MAPK/ERK1/2 Activation in Gingival Fibromatosis.

doi:10.1016/j.identj.2026.109775

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Article

KCNK4 c.730G>C/p.Ala244Pro Promotes Gingival Fibroblast Proliferation and Fibrosis Through MAPK/ERK1/2 Activation in Gingival Fibromatosis.

International dental journal - 1 Oct 2026

Wu Yantong, Yang Shuran, Kong Fanying, He Ming, Zhang Yan, Zhang Shengnan, Zhou Hongxian, Yang Ruoxi, Mao Yongjian, Shi Hong, Zhang Jie, Zhang Mingzhu

Abstract excerpt

INTRODUCTION AND AIMS: KCNK4-associated gingival fibromatosis (K-GF) is a rare condition characterised by progressive gingival enlargement and excessive connective tissue accumulation. Although pathogenic variants in KCNK4 have been linked to syndromic gingival overgrowth, the cellular and molecular mechanisms underlying the gingival phenotype remain incompletely understood. This study aimed to investigate the...

Read the complete abstract on PubMed

Topics

Fibromatosis, Gingival
Cell Proliferation
Humans
Fibroblasts
Animals
Fibrosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

MAP Kinase Signaling System

Gingiva

Apoptosis

Mutation

Potassium Channels, Tandem Pore Domain

Male

Cells, Cultured

Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 42526279
DOI: 10.1016/j.identj.2026.109775
PMCID: PMC13451886

Genes

KCNK4
CCK

Variants

Provenance

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