Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing.

doi:10.1016/j.biopsych.2023.08.023

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Article

Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing.

Biological psychiatry - 15 Apr 2024

Johnston Keira J A, Cote Alanna C, Hicks Emily, Johnson Jessica, Huckins Laura M

Abstract excerpt

BACKGROUND: Chronic pain is a common, poorly understood condition. Genetic studies including genome-wide association studies have identified many relevant variants, which have yet to be translated into full understanding of chronic pain. Transcriptome-wide association studies using transcriptomic imputation methods such as S-PrediXcan can help bridge this genotype-phenotype gap. METHODS: We carried out...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37678542
DOI: 10.1016/j.biopsych.2023.08.023
PMCID: PMC10924073

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