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Article

Genetic and Epigenetic Mechanisms Underlying Phenotypic Discordance in Monochorionic Monozygotic Twins: A Systematic Review.

Genes - 21 Jul 2026

Colacurci Dario, Maruotti Giuseppe Maria, Saccone Gabriele, D'Agostino Anna Maria, De Santis Maria Virginia, Riccardi Mariagrazia, Martirani Mirko, Guida Maurizio, Sarno Laura

Abstract excerpt

BACKGROUND: Monochorionic twin pregnancies provide a unique model to investigate fetal phenotypic discordance, because both fetuses share a single placenta and interconnected vascular circulation. Although most monochorionic twins are monozygotic, clinically relevant differences may arise through genetic, epigenetic, placental, and stochastic developmental mechanisms. METHODS: This systematic review was conducted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42510871
DOI: 10.3390/genes17070832
PMCID: PMC13411809

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