Article
Some causes of genotypic and phenotypic discordance in monozygotic twin pairs.
American journal of medical genetics - 22 Jan 1996
Machin G A
Abstract excerpt
The use of the adjective "identical" rather than monozygotic leads to misunderstandings about the biology of monozygotic twinning. Most monozygotic twin pairs are not identical; there may be major discordance for birth weight, genetic disease, and congenital anomalies. These indicate that postzygotic events may lead to the formation of two or more cell clones in the inner cell mass and early embryo that actually...
Topics
- Chorion
- DNA
- Dosage Compensation, Genetic
- Embryonic and Fetal Development
- Female
- Genetic Variation
- Genotype
- Humans
- Male
- Models, Genetic
- Mosaicism
- Mutation