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Discordant congenital heart defects in monochorionic twins: Risk factors and proposed pathophysiology

6 May 2021

Abstract excerpt

A six-fold increase in congenital heart defects (CHD) exists among monochorionic (MC) twins compared to singleton or dichorionic twin pregnancies. Though MC twins share an identical genotype, discordant phenotypes related to CHD and other malformations have been described, with reported rates of concordance for various congenital anomalies at less than 20%. Our objective was to characterize the frequency and...

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PMID: 33956871
DOI: 10.1371/journal.pone.0251160

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