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Article

Exploring of pyrazinamidase recombinant activity from PZA-sensitive and resistant Mycobacterium tuberculosis expressed in Escherichia coli BL21 (DE3).

Brazilian journal of biology = Revista brasleira de biologia - 1 Jan 2024

Purkan P, Hadi S, Retnowati W, Sumarsih S, Wahyuni D K, Piluharto B, Panjaitan T M, Ifada C, Nadila A, Nabilah B A

Abstract excerpt

The mutations of pncA gene encoding pyrazinamidase/PZase in Mycobacterium tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates showed significant phenotypic differences to PZA. The H isolate was PZA sensitive, but R1 was PZA resistant up to 100 ug/ml. The paper reports the pncA profile for both isolates and the activity of their protein expressed in Escherichia coli BL21(DE3)....

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PMID: 38422295
DOI: 10.1590/1519-6984.278911

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