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Article

Understanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail.

European journal of clinical pharmacology - 1 Jul 2024

Dong Qian, Chen Chunli, Taubert Max, Bilal Muhammad, Kinzig Martina, Sörgel Fritz, Scherf-Clavel Oliver, Fuhr Uwe, Dokos Charalambos

Abstract excerpt

PURPOSE: Adefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenotyping study to assess renal organic anion transporter 1 (OAT1), with renal clearance (CLR) as the primary parameter describing renal elimination. An approximately 20% higher systemic exposure of adefovir was observed when combined with other cocktail components (metformin, sitagliptin, pitavastatin, and digoxin)...

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Identifiers

PMID: 38546841
DOI: 10.1007/s00228-024-03673-x
PMCID: PMC11156719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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