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Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10 250 participants from the HostSeq cohort.

Genome - 1 Jan 2026

Warren René L, Coombe Lauren, Birol Inanc

Abstract excerpt

Accurate characterization of human genetic diversity is essential for robust genomic analyses. We compared self-declared and genome-derived ancestry composition in 10 250 participants from the pan-Canadian HostSeq cohort using whole-genome sequencing data. Global and local ancestry were inferred at the continental super-population level using the alignment-free ntRoot algorithm and evaluated through both...

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PMID: 42492085
DOI: 10.1139/gen-2026-0022

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