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Article

Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling.

Molecular oncology - 1 Jul 2023

Teleanu Maria-Veronica, Fuss Carmina T, Paramasivam Nagarajan, Pirmann Sebastian, Mock Andreas, Terkamp Christoph, Kircher Stefan, Landwehr Laura-Sophie, Lenschow Christina, Schlegel Nicolas, Stenzinger Albrecht, Jahn Arne, Fassnacht Martin, Glimm Hanno, Hübschmann Daniel, Fröhling Stefan, Kroiss Matthias

Abstract excerpt

Parathyroid carcinoma (PC) is an ultra-rare malignancy with a high risk of recurrence after surgery. Tumour-directed systemic treatments for PC are not established. We used whole-genome and RNA sequencing in four patients with advanced PC to identify molecular alterations that could guide clinical management. In two cases, the genomic and transcriptomic profiles provided targets for experimental therapies that...

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Identifiers

PMID: 36808802
DOI: 10.1002/1878-0261.13398
PMCID: PMC10323885

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