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Article

Whole-exome Sequencing of Atypical Parathyroid Tumors Detects Novel and Common Genes Linked to Parathyroid Tumorigenesis.

The Journal of clinical endocrinology and metabolism - 18 Dec 2024

Pardi Elena, Poma Anello Marcello, Torregrossa Liborio, Pierotti Laura, Borsari Simona, Della Valentina Simone, Marcocci Claudio, Cetani Filomena

Abstract excerpt

CONTEXT: Atypical parathyroid tumor (APT) represents a neoplasm characterized by histological features typical of parathyroid carcinoma (PC) but lacking local infiltration and/or distant metastasis, leading to uncertainty regarding its malignant potential. OBJECTIVE: To characterize the molecular landscape and deregulated pathways in APT. METHODS: Whole-exome sequencing (WES) was conducted on 16 APTs. DNA from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38940486
DOI: 10.1210/clinem/dgae441

Genes

PC
PI3
BCOR
CDC73
MEN1
MTOR
PIK3CA
ATM
CLMN
COL4A5
JAM2
KDM2A
MBD4
MED12
MUC16
OR1S1
PIK3CB
UBR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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