A molecular glue to take down mutant BRAF.

doi:10.1126/scisignal.aek4190

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A molecular glue to take down mutant BRAF.

Science signaling - 14 Jul 2026

Ferrarelli Leslie K

Abstract excerpt

A molecular glue degrader tackles mutant BRAF in drug-resistant colorectal cancer by disrupting mRNA splicing.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Drug Resistance, Neoplasm
Share to BRAF gene
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

Share to RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 42447212
DOI: 10.1126/scisignal.aek4190

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

A molecular glue to take down mutant BRAF.PMID 42447212Read ↗

mRNA splicing variants: exploiting modularity to outwit cancer therapy.Semantic proximity Read ↗

Modular RNA-based PROTACs for selective degradation of multidomain RNA-binding proteinsSemantic proximity Read ↗

Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicingSemantic proximity Read ↗

CRISPR editing of <i>sftb-1</i> /SF3B1 in <i>C. elegans</i> allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicingSemantic proximity Read ↗

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer.Semantic proximity Read ↗

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinerySemantic proximity Read ↗

mRNA Therapies: New Hope in the Fight against Melanoma.Semantic proximity Read ↗

Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNASemantic proximity Read ↗

Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded librariesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.