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Danish children with ZZ-homozygous alpha-1 antitrypsin deficiency are more affected on liver parameters than children with heterozygosity.

Acta paediatrica (Oslo, Norway : 1992) - 1 Mar 2024

Winther Christina Louise, Nyrann Sofie, Gaardskaer Nielsen Rasmus, Duno Morten, Johansen Klaus Birkelund, Helt Thora Wesenberg, Brix Christensen Vibeke

Abstract excerpt

AIM: The longitudinal health status of Danish children with alpha-1 antitrypsin deficiency had never previously been characterised. This study aimed to assess the changes in growth, lung and liver function through childhood in these children. METHODS: Danish children diagnosed between 2005 and 2020 with pathogenic variants in the Serpin family A member 1 gene were included. Retrospective data on growth, lung and...

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PMID: 38009616
DOI: 10.1111/apa.17048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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