An Iridium(III) Complex Induces Immunogenic Methuosis and Reprograms Tumor-Associated Macrophages for Chemoimmunotherapy against KRAS-Mutated Tumors.

Abstract excerpt

Effective chemoimmunotherapy necessitates strategies capable of concurrently eliminating malignant cells and reprogramming the immunosuppressive tumor microenvironment. However, therapeutic outcomes are often compromised by tumor-associated macrophages (TAMs), and existing nanomedicine-based cotargeting approaches encounter considerable translational challenges. Here, we report Ir-estin, an iridium(III) complex...

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