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Unusual enrichment of rare C-to-G transversions in the SARS-CoV-2 delta spike.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2026

Kakeya Hideki

Abstract excerpt

SARS-CoV-2 evolution is typically characterized by strong mutational biases, with C → G transversions being consistently rare. This study investigates a unique violation of this constraint specifically within the Delta variant spike protein. By analyzing nucleotide substitution spectra from GenBank sequences, we compared C → G transversion frequencies across early variants, Omicron, and Delta lineages, including...

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PMID: 42435927
DOI: 10.1016/j.meegid.2026.105989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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