Genetic variants of TNF-α and PTPN22 and their association with Hashimoto's thyroiditis in patients with chronic spontaneous urticaria from the Colombian Caribbean.

Abstract excerpt

OBJECTIVE: To evaluate the association of TNF-α promoter polymorphisms (rs361525, rs1800629) and the PTPN22 rs2476601 variant with the coexistence of CSU and HT in an admixed Caribbean Colombian population. METHODS: A retrospective case-control study was conducted in 86 patients with confirmed CSU (45 with CSU-alone and 41 with CSU+HT). Single-nucleotide polymorphism (SNP) genotyping was performed using TaqMan®...