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Article

Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses.

Viruses - 26 Mar 2020

Lutz Iv Michael M, Dunagan Megan M, Kurebayashi Yuki, Takimoto Toru

Abstract excerpt

Influenza A viruses (IAVs) are a significant human pathogen that cause seasonal epidemics and occasional pandemics. Avian waterfowl are the natural reservoir of IAVs, but a wide range of species can serve as hosts. Most IAV strains are adapted to one host species and avian strains of IAV replicate poorly in most mammalian hosts. Importantly, IAV polymerases from avian strains function poorly in mammalian cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32224899
DOI: 10.3390/v12040365
PMCID: PMC7232137

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