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Characterization of an MHC class II b gene reveals high heterogeneity and polymorphism among populations of non-native bullfrogs with complex invasion histories.

Journal of genetics - 1 Jan 2026

Segovia Luisa N, Kiemnec-Tyburczy Karen M

Abstract excerpt

We characterized the genetic diversity of exon 2 of one major histocompatibility complex (MHC) Class II b chain gene in five non-native populations of the American bullfrog (Aquarana (Rana) catesbeiana)-a highly invasive amphibian. We discovered higher levels of genetic diversity and more signatures of positive selection in the MHC exon relative to a putatively neutral protein coding gene (Cytochrome b)....

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PMID: 42417070

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