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Article

Assessing measurement bias in substance withdrawal symptoms attributable to childhood adversity and genetic liability.

Drug and alcohol dependence - 1 Sept 2026

Han Angela, Soohoo Jackson, Gelernter Joel, Feinn Richard, Kranzler Henry R, Davis Christal N

Abstract excerpt

BACKGROUND: Substance withdrawal results from the abrupt cessation or reduction of substance use in physically dependent individuals. Diagnosis of withdrawal requires endorsing multiple substance-specific symptoms, implicitly assuming that all symptoms are equally indicative of underlying withdrawal severity. However, some criteria may be more informative than others, and their endorsement may be impacted by...

Read the complete abstract on PubMed

Topics

Humans
Substance Withdrawal Syndrome
Adverse Childhood Experiences
Female
Male
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Risk Score

Bias

Substance-Related Disorders

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42413283
DOI: 10.1016/j.drugalcdep.2026.113261

Provenance

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