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Article

Live human metapneumovirus vaccine candidates attenuated by temperature sensitivity mutations from human respiratory syncytial virus.

Journal of virology - 18 Aug 2026

Lamichhane Pramila, Yang Lijuan, Santos Celia, Park Hong-Su, Ou Li, Zhou Tongqing, Le Nouën Cyril, Buchholz Ursula J

Abstract excerpt

Human metapneumovirus (HMPV, genus Metapneumovirus) and respiratory syncytial virus (HRSV, genus Orthopneumovirus) are pediatric respiratory pathogens of the Pneumoviridae family. We previously developed live-intranasal HRSV vaccine candidates attenuated by genetically stabilized temperature sensitivity/attenuating (ts/att) mutations in the HRSV polymerase (L) ORF, including sites "1030s" (L codon changes...

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Identifiers

PMID: 42405774
DOI: 10.1128/jvi.00692-26
PMCID: PMC13483368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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